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The Habitual program is based on decades of research, across multiple disciplines

Put type 2 diabetes into remission

The DiRECT Trial showed us that remission is not only possible, it is acheivable for many type 2 diabetics. [1]

Reduce the risk of heart attack and stroke

Following a 12 week TDR and ongoing behaviour change program, at 24 months, patients in remissions’ Q-RISK was about half of control . That’s half the risk of a stroke in the next 10 years. [2]

Hands-down the best non-surgical approach to reversing type 2 diabetes

kilogrammes
average weight loss at 12 months [3]
of people
stopped or reduced medication [3]

Remission at one year

TDR and behaviour change in combination have been shown to help a significant proportion of study participants reach remission from type 2 diabetes at 1-year.

Reversing the ‘twin cycles’ of type 2 diabetes

A simplified diagram illustrating the proposed mechanism behind type 2 diabetes reversal. Adapted from Taylor et al.[6]

The Habitual programme is based on the latest scientific breakthroughs and decades of diabetes research

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Lean et al, 2018
Read more

Nutritional basis of type 2 diabetes remission

Lean et al, 2021
Read more

Understanding the mechanisms of reversal of type 2 diabetes

Taylor et al, 2019
Read more

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim et Al
Read more

Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

Look AHEAD Research Group, 2013
Read more

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean et al, 2019
Read more

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes

Riddle et al, 2021
Read more

Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

Al-Mrabeh et al, 2020
Read more

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial

Taheri et al, 2020
Read more

Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/ weight management programme

Xin et al, 2020
Read more

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery

Taylor et al, 2018
Read more

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Lean et al, 2018
Read more

Nutritional basis of type 2 diabetes remission

Lean et al, 2021
Read more

Understanding the mechanisms of reversal of type 2 diabetes

Taylor et al, 2019
Read more

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim et Al
Read more

Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

Look AHEAD Research Group, 2013
Read more

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean et al, 2019
Read more

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes

Riddle et al, 2021
Read more

Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

Al-Mrabeh et al, 2020
Read more

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial

Taheri et al, 2020
Read more

Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/ weight management programme

Xin et al, 2020
Read more

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery

Taylor et al, 2018
Read more

References

[1] Lean, M et al. (2018). Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 391(10120), 541–551.
[2] Lean, M et al. (2019). Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes and Endocrinology, 7(5), 344–355.
[3] Habitual Beta. Internal Data.
[4] Saslow LR et al. (2018). Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study JMIR Diabetes, 3(3):e12
[5] Taheri, S et al. (2020). Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. Lancet Diabetes and Endocrinology, 8, 477–489.
[6] Taylor, R et al. (2019). Understanding the mechanisms of reversal of type 2 diabetes. In The Lancet Diabetes and Endocrinology (Vol. 7, Issue 9, pp. 726–736).

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